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ASD Subgroup Linked to Brain Volume

By Shana R. Spindler, PhD on October 7, 2014


Background: Autism Spectrum Disorder (ASD) features a diverse set of social and behavioral deficits, language abilities, and skill sets. Identifying unique subgroups in the ASD population is a major goal within the autism research community. Given that individuals within a subgroup may share causal risk factors, a subgroup diagnosis could enable targeted therapy options.


What’s new: Researchers in the United Kingdom have identified a subgroup of ASD based on language delay in childhood. The team used a technique called voxel-based morphometry to measure brain volumes in 80 adult men with ASD. Of the participants, 38 experienced childhood language delay with 42 reporting normal language development. Individuals with delayed language had an overall larger volume of brain grey matter than those with typical language histories. When the team measured specific brain areas, they found several clusters of decreased volume in those with language delay.


Why it’s important: Last year, the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5) grouped anyone along the autism spectrum into a single diagnosis of ASD. This study highlights the need to assess individual traits within individuals on the spectrum as we work towards understanding the underlying biology of ASD subgroups.

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