Research Advances > Stem Cells > Induced pluripotent cells

What Is an Induced Pluripotent Stem Cell?

So far we have described embryonic stem cells and adult stem cells. Generally speaking, embryonic stem cells can turn into any of the specialized cells found in an adult. While adult stem cells can only turn into the specialized cells found from the tissue that they were found in (for example, a brain stem cell would be able to turn into a neuron but not any of the cells found in the liver).


How this type of stem cell is made

It has been assumed that once a stem cell has differentiated into a specialized cell, there was no way for that cell to go back and become a stem cell again. In 2006, a breakthrough study came out which demonstrated how a fully developed cell could be induced back to a pluripotent embryonic stem cell-like state1.  This process of going back was called de-differentiation and was accomplished by the use of a virus that was specially designed and built to reprogram the cell.

The following year, it was shown that human fibroblasts could likewise be reprogrammed into a pluripotent stem cell-like state2-3.  These reprogrammed cells are called induced pluripotent stem cells (iPSCs) and are thought to be capable of differentiating into every specialized cell type in the human body.

Click here to learn about how induced pluripotent stem cells are generated.


Use of iPSCs in research

Like other stem cells, the environment in which iPSCs are cultured can be manipulated to direct their differentiation into the different specialized cell types in the human body, including neurons and other non-neuronal cells of the brain. Research like this is being done with iPSCs to help identify potentially useful drugs and to model human diseases.

Click here to learn how iPSCs are different than embryonic stem cells.

  1. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultured by defined factors. Cell 126(4): 664-676. PMID: 16904174.
  2. Yu J, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318(5858): 1917-1920. PMID: 18029452.
  3. Takahashi K, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5): 861-872. PMID: 18035408.
  4. Liu H, Zhang SC (2011) Specification of neuronal and glial subtypes from human pluripotent stem cells. Cell Mol. Life Sci. 68(24): 3995-4008. PMID: 21786144.
  5. Urbach A, et al. (2010) Differential modeling of Fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell 6(5): 407-411. PMID: 20452313.